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If they can find target genes that influence atherosclerosis, scientists can then explore the effects of existing drugs or develop new ones. Al-Siraj said his next step is to study the role of the number of X chromosomes in atherosclerosis.

These findings may also drive choice of diet for post-menopausal women. Cassis said, "For example, if they're very effective fat absorbers, obviously, once they get post-menopausal, they need to be careful about the fat content.

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Home Genetics Home Cardiology. Yasir Al-Siraj R is first author of a paper in Nature Communications that demonstrates the role of XX chromosomes in heart disease risk.

Credit: University of Kentucky Ben Corwin. Explore further. DOI: Provided by University of Kentucky.

This document is subject to copyright. Keeping a normal potassium level is imperative for hydration and thus preventing muscular cramps associated with electrolyte mineral loss.

Dandelion root has also been shown to have antioxidant and anti-inflammatory properties, as well as having beneficial effects on insulin sensitivity and fat metabolism.

Uvi ursi is an evergreen shrub which is perhaps more commonly referred to as bearberry, due to the fact that bears have a penchant for the eating of its fruit.

Uvi ursi has historically been used since the 2nd century by ancient cultures for its known antibacterial properties which may alleviate bladder and urininary infections.

Uvi ursi may also have a mild diuretic effect. A diuretic aids the body in maintaining a natural water balance, flushing excess water our of your system which may have also have several positive effects on your health.

Letting go of excess water, which can be a problem for a lot of women during menstruation will certainly help you maintain a leaner look. Although acai berries are relatively new to the supplement industry, these berries have been consumed for centuries by indigenous Amazonian people for its energy boosting properties.

Laboratory tests show that acai berries yield a high concentration of potent natural antioxidants such as sterols and anthocyanin.

Capsaicin is the primary active ingredient in cayenne. Capsaicin is involved in pain mediation and also has anti-inflammatory properties.

It also has a protective effect on the lining of the stomach. In addition, it has beneficial effects on circulation.

Full body blood circulation can be important in fat burning by ensuring fat is mobilised via the blood from all areas of your body. Cayenne also has a significant thermogenic effect, in which you can actually feel your body temperature raise, a side effect when your body burns fat as fuel.

Bioperine is a nutrient absorbent enhancer and has been shown to increase the bioavailability of nutritional ingredients.

It has therefore been added to our formula to further enhance the bioavailability and nutrient synergy of all ingredients and thus further enhancing the formulas fat burning effects.

L-Tyrosine is a non-essential amino acid the body can manufacture it from other amino acids. However, it is essential for the manufacture of catecholamine neurotransmitters such as dopamine, dihydroxyphenylalanine DOPA , norepinephrine, and epinephrine.

Variations in neurotransmitter concentrations have been shown to result in a variety of physiological and psychological changes.

For example, reduction in brain catecholamines have been found in association with depression and memory deficits.

L-Tyrosine has also been found to minimise or reverse stress-induced performance decrement by increasing depleted pools of norepinephrine.

L-Tyrosine is the precursor for the hormones thyroxine and triiodothyronine produced in the thyroid gland and which are responsible for changes in metabolic rate.

L-Tyrosine is also one of the precursors to human growth hormone which is a lipolytic breakdown of fat polypeptide hormone.

The leading cause of death in women is coronary artery disease CAD , but women develop CAD almost 10 years later than men.

For many years, scientists attributed this decade-long delay in disease development to the protective effects of sex hormones. There is a lot of evidence that hormones like estrogen and progesterone protect the heart, but scientists had little data on the influence of the genetic component -- the X chromosome -- on the heart.

A team led by Lisa Cassis, a researcher in the UK College of Medicine's pharmacology and nutritional sciences department, set out to understand the role of sex chromosomes in the cardiovascular system.

Cassis's team studies chromosome effects in mice, and for this most recent discovery they were able to zero in on XX chromosomes by removing hormones.

According to Yasir Al-Siraj, a postdoctoral scholar and the paper's first author, if the levels of circulating lipids transported by the blood are too high, they will start to accumulate in and on the artery wall, leading to plaque buildup.

These plaques harden and narrow the artery, reducing blood flow to the vital organs. The team looked at lipids absorbed from the diet and made in the liver.

Cassis, who also serves as the UK vice president for research, said, "We looked at how our X sex chromosomes were influencing the levels of lipids in the blood and in the arteries.

Women need fat to bear and feed babies, Cassis explained: "We're set up, potentially through our XX sex chromosomes, so that we can effectively absorb that lipid from the diet and put it into our fat cells and maybe even make it in the liver.

Everything is fine until women hit menopause and the protective effects of hormones disappear, leaving women with what Cassis calls "that XX thrifty, fat-absorbing kind of genotype.

The team is looking at genes that are changed in the liver and in the intestine to find novel targets for drug development.

If they can find target genes that influence atherosclerosis, scientists can then explore the effects of existing drugs or develop new ones.

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